Abstract: The long-term mid-infrared variability amplitude of Broad-line Seyfert 1 (BLSy1) galaxies and Narrow-line Seyfert 1 (NLSy1) galaxies were compared using archival data from the Wide-field Infrared Survey Explorer (WISE). Additionally, the correlation between the long-term mid-infrared variability amplitude and common active galactic nucleus parameters was analyzed, using samples that included BLSy1 galaxies, NLSy1 galaxies, and a combined sample of both BLSy1 and NLSy1 galaxies. The main results are as follows: (1) The long-term mid-infrared variability amplitude of BLSy1 galaxies is greater than that of NLSy1 galaxies possibly due to differences in the accretion disk structure between BLSy1 and NLSy1 galaxies. Correlation analysis suggests that the larger long-term mid-infrared variability amplitude in BLSy1 galaxies compared to NLSy1 galaxies may be mainly attributed to differences in Eddington ratio between the two types of galaxies. (2) The long-term mid-infrared variability amplitudes of BLSy1 galaxies, NLSy1 galaxies, and the combined sample are significantly negatively correlated with the 5100 Å luminosity, Eddington ratio and FeII emission line strength. The long-term mid-infrared variability amplitude of NLSy1 galaxies is significantly positively correlated with the OIII \lambda 5007 emission line strength.